Variables Methylation+(32) Methylation-(16)   Age <65 18 7 0.414 >65 14 9   HBV 7 0 0.042* HCV 23 15   Patho mod+poor 29 14 0.738 well 3 2   Size <50 23 12 0.818 >50 9 4   Size <30 15 7 0.838 >30 17 9   Size <20 7 1 0.171 >20 25 15   Number solitary 21 10 0.831 multiple 11 6   eg 26 15 0.462 ig 4 1   fc- 5 2 0.772 fc+ 27 14   fc-inf- 5 2 0.741 fc-inf+ 26 14   vp- 25 14 0.553 vp+ 6 2   vv- 31 15 0.159 vv+ 0 1   vp or vv- 25 13 0.802 vp or vv+ 7 3   z1 12 13 0.004* z2 20 3   stage12 22 10 0.665 stage34 10 6   AFP <20 9 10 0.022* >20 23 6   ChildA 30 13 0.181 ChildB 2 3   Alb <3.5 5 16 <0.001* >3.5 27 0   PT <80 21 11 0.829 >80 11 5   R15 <10 13 4 0.286 >10 19 12   Damage A 18 11 0.404

Table 4: Clinicopathological Features and Results of STEAP4 Hypermethylation in HCC. patho: pathological findings, mod+poor: moderately or poorly differentiated, well: well differentiated, Eg: expansive growth, ig: infiltrative growth, fc: formation of capsule, fcinf: infiltration to capsule, vp: portal vessel invasion, vv: venus vessel invasion, z: liver cirrhosis, AFP: alpha feto protein, Alb: albumin value, PT: prothrombin time, R15: ICG R15, damage: degree of liver damage.