Figure 1: NFAT signaling in pancreatic cancer cells: Inactive cytosolic NFAT proteins are dephosphorylated by calcineurin in response to oncogenic cytokines, and elevated intracellular Ca2+ concentrations, allowing their nuclear translocation. In the nucleus,active NFAT proteins either become ubiquitinated for proteosomal degradation or are stabilized by GSK3β-dependent phosphorylation, thus allowing interaction with partner transcription factors on distinct target genes.