Risk factors
Cases, N (%)
Controls, N (%)
Adjusted OR (95% CI)
a
P
Net BPDE-induced & GERD
Low & GERD(-)
29 (20.3)
76 (63.3)
1.00 (ref.)
High & GERD(-)
23 (16.1)
24 (20.0)
2.05 (0.94-4.47)
0.070
Low & GERD(+)
61 (42.7)
14 (11.7)
4.83 (2.14-10.87)
<0.001
High & GERD(+)
30 (20.9)
6 (5.0)
11.54 (3.84-34.93)
<0.001
P for interaction
0.835
Net BPDE-induced & smoking status
Low & never smoking
19 (13.3)
44 (36.7)
1.00 (ref.)
High & never smoking
15 (10.5)
11 (9.2)
2.96 (0.88-10.00)
0.081
Low & ever smoking
71 (49.7)
46 (38.3)
3.83 (1.61-9.11)
<0.001
High & ever smoking
38 (26.5)
19 (15.8)
7.26 (2.80-18.84)
<0.001
P for interaction
0.548
Net γ radiation-induced & GERD
Low & GERD(-)
34 (20.4)
92 (63.0)
1.00 (ref.)
High & GERD(-)
27 (16.2)
30 (20.5)
2.64 (1.30-5.37)
0.007
Low & GERD(+)
75 (44.9)
18 (12.3)
6.42 (3.09-13.37)
<0.001
High & GERD(+)
31 (18.5)
6 (4.1)
9.85 (3.50-27.71)
<0.001
P for interaction
0.420
Net γ radiation-induced & smoking status
Low & never smoking
32 (19.2)
50 (34.2)
1.00 (ref.)
High & never smoking
7 (4.2)
18 (12.3)
1.14 (0.36-3.58)
0.823
Low & ever smoking
77 (46.1)
60 (41.2)
2.25 (1.08-4.70)
0.030
High & ever smoking
51 (30.5)
18 (12.3)
6.93 (2.92-16.45)
<0.001
P for interaction
0.152
Table 4:
Joint effects of DNA damage, GERD status, and smoking status.
a
Adjusted by sex, age, BE, family history of all cancer.
