| Histotype |
Grade |
Frequency (%) |
Pathogenesis |
Cell of origin |
Precursor lesion |
Common somatic mutations |
Type |
References |
| Brenner |
Low-grade |
<1 |
Stepwise |
FTE |
Benign Brenner tumor |
KRAS
PIK3CA |
I |
[9,10] |
| Mucinous |
|
5 |
Stepwise/
De novo |
Unknown |
Adenoma
Mucinous Borderline tumor
Teratoma
Endometriosis |
BRAF
KRAS
RNF43
TP53 |
I |
[6,12] |
| Clear cell |
|
5 |
Stepwise |
Endometrium |
Endometriosis
Borderline tumor
Adenofibroma |
ARID1A,
KRAS,
PIK3CA,
PPP2R1A |
I |
[6,8] |
| Endometrioid |
Low-grade |
10 |
Stepwise |
Endometrium |
Endometriosis
Borderline tumor
Adenofibroma |
CTNNB1
KRAS
MLH2
MLH6
MSH1
PIK3CA
PTEN |
I |
[6,13] |
| |
High-grade |
|
Stepwise |
Endometrium |
Endometriosis
Borderline tumor
Adenofibroma |
PPP2R1A
TP53 |
II |
[6,13] |
| Serous |
Low-grade |
5 |
Stepwise |
FTE |
Serous borderline tumor |
KRAS
BRAF |
I |
[6,7] |
| |
High-grade |
70 |
De novo |
FTE |
Serous tubal intraepithelial carcinoma |
BRCA1
BRCA2
TP53 |
II |
[6,11,16] |
|