Populatiom sub-groups Genotype Cases/Controls OR (95% CI) p- value Ethnicity         Kazakh GG 17/11 1.84 (0.73 – 4.62) 0.19 GT+TT 26/31 0.54 (0.22 – 1.36) Russian GG 39/23 2.10 (1.07 – 4.10) 0.03 GT+TT 38/47 0.48 (0.24 – 0.93) Age         ≤60 GG 14/14 0.83 (0.34 – 2.02) 0.68 GT+TT 35/29 1.21 (0.50 – 2.94) >60 GG 43/21 3.13 (1.59 – 6.17) 0.0008 GT+TT 34/52 0.32 (0.16 – 0.63) Sex         Male GG 22/8 3.96 (1.52 – 10.31) 0.004 GT+TT 25/36 0.25 (0.10 – 0.66) Female GG 35/27 1.33 (0.69 – 2.54) 0.4 GT+TT 44/45 0.75 (0.39 – 1.45) Smoking status         Never GG 30/28 1.88 (0.97 – 3.62) 0.06 GT+TT 36/63 0.53 (0.28 – 1.03) Ever GG 16/6 2.53 (0.81 – 7.89) 0.11 GT+TT 19/18 0.40 (0.13 – 1.24) Alcohol consumption         Positive GG 12/6 2.94 (0.92 – 9.36) 0.06 GT+TT 17/25 0.34 (0.11 – 1.08) Negative GG 34/28 1.79 (0.94 – 3.42) 0.08 GT+TT 38/56 0.56 (0.29 – 1.07)

Table 3: Association analysis based on ethnicity, age, gender, smoking and alcohol status.