| Variables | No. of    patients | Mean    survival (months) | 14 months    PFS proportion (%) | P value | 
      
        | Concurrent    methylation status of  all three MGMT,    TP53 and CDKN2A | MMM | 6 | 13.20(11.80-14.60) | 80 | 0.131 | 
      
        | UUU | 5 | 10.60(6.86-14.34) | 30 | 
      
        | Combinations    of prognostic analysis of concurrent MGMT:TP53 methylation | M     M | 10 | 11.44(8.75-14.13) | 68.6 | 0.172 | 
      
        | U      U | 8 | 9.25(5.84-12.66) | 25 | 
      
        | Combinations    of prognostic analysis of concurrent MGMT:CDKN2A methylation | M     M | 13 | 12.72(11.41-14.04) | 55 | 0.352 | 
      
        | U      U | 8 | 10.36(7.02-13.73) | 41.7 | 
      
        | Combinations    of prognostic analysis of concurrent TP53: CDKN2A methylation | M     M | 7 | 11.88(9.22-14.56) | 68.6 | 0.479 | 
      
        | U         U | 24 | 11.79(10.35-13.24) | 60.2 |