MOC Mechanism Genes Up/Down Regulation Chemoprotection/ chemoresistance 1a Drug Uptake SLC22A1 Down Increased SLC22A5 Up Decreased SLC28A1 Down Increased 1b Drug Export ATP7A Up Increased ABCB1 Up Increased ABCC2 Up Increased ABCG2 Up Increased ABCC6 Down Decreased MVP Down Decreased 2 Drug Metabolism CES1 Down Decreased CYP1A2 Down Decreased GSTA1 Down Decreased UPP1 Up Increased 3 Drug Targets DHFR Down Increased   TOP1 Up Increased 4 DNA Repair None     5a Apoptosis BCL2L1 Up Increased BIRC3 Up Increased DIABLO Down Decreased 5b Survival BCL2L1 Up Increased BIRC5 Up* Increased MAPK1 Up Decreased MYC Up* Increased NAIP Up Increased NFKB1 Up Increased PIK3CG Up Increased RPL6 Up* Increased XIAP Up Increased

Table 1: Changes in the expression of genes involved in chemoresistance/chemoprotection in HB.