Figure 1. Immunomodulatory role of cancer stem cells (CSCs). Schematic diagram that summarizes the immunosuppressive role of CSC. PGE2= Prostaglandins E2, MIC= macrophage inhibitor cytokine 1, TGF-b1= Tumor growth factor beta 1 CCL2= , T-reg= Regulatory T-cells. Straight line () indicates evidence supported effect while a dotted line () indicates a possible/plausible mechanism.