Figure 4: NOV-002 suppresses metastasis in combination with gemcitabine in a mouse model. (A) Bioluminescence imaging of lung metastasis and primary tumor. Images were taken five weeks following the treatment of control (PBS), NOV-002, gemcitabine or combination of NOV-002 and gemcitabine following the transplantation of breast cancer 4T1 cells in mammary fat pads. (B) Quantification of primary tumor growth with treatment of control (PBS), NOV-002, gemcitabine or combination of NOV-002 and gemcitabine following the transplantation of breast cancer 4T1 cells in mammary fat pads. (C) Quantification of metastasis growth after five weeks’s treatment of control (PBS), NOV-002, gemcitabine or combination of NOV-002 and gemcitabine following the transplantation of breast cancer 4T1 cells in mammary fat pads.12.