E×trinsic pathway of apoptosis

Cellular compartment

Reactions

Km (µM)

Vmax (µmol/mg/min)

E×tracellular space and membrane

DL + DR → [email protected]

1

1×10-5

DL + DecoryR → [email protected]

1

1×10-5

Cytosol

DR* + FADD + Cas8 → Cas8*

4.5

5.8×10-5

Cas8* + ProCas3 → Cas3*

50

5×10-5

Intrinsic pathway of apoptosis

Cellular compartment

Reactions

Km (µM)

Vmax (µmol/mg/min)

Mitochondria/
Cytosol

BakR* + Smac → Smac @ cytosol

0.5

5×10-6

BidR* + AIF → AIF @ cytosol

0.3

2×10-5

Bcl2R* + CytC→ CytC @ cytosol

0.1

8×10-7

Mitochondrial membrane

Bak + BakR → BakR* @ mitochondria

0.1

5.8×10-5

Note: The symbol [email protected] on the right side of an equation indicates the cellular compartment in which the resultant reactant must be registered.
Table 3: Modelling the signal components belonging to pro-apoptosis signalling pathways.