Residues Hypothetical function Q164E Adjacent to the guanosine binding pocket E168D Adjacent to the guanosine binding pocket N197H Adjacent to the guanosine binding pocket A206P Adjacent to the guanosine binding pocket T217E Phosphorylatable T227S Phosphorylatable V320I Adjacent to aminoacyl-tRNA and eEF1Bα binding sites A326C Adjacent to an actin binding residue N331S Actin binding M335Q Actin binding A358S Adjacent to an actin binding residue F393S Phosphorylatable A445S Phosphorylatable

Table 3: Hypothetical residues estimated from the human eEF1A1 and eEF1A2 structure models and potential phosphorylatable residues [40].