Table5: Comparison of the common virulence factors namely, pneumococcal surface protein A (PspA), autolysin (LytA), hyaluronate lyase (Hyl), pneumolysin (Ply), neuraminidase A (NanA), neuraminidase B (NanB), choline binding protein A (CbpA), pneumococcal surface antigen A (PsaA) and immunoglobulin A1 (IgA1) S. pneumoniae. LALIGN program is used to find identity between sequences. NA - Not Available * Nan-ptv: Neuraminidase, putative ** N.lyase-ptv: N-acetylneuraminate lyase, putative *** Role category functions 1. Cell envelope; cellular process – pathogenesis 2. Mobile and extra chromosomal element function: transposon function 3. Cell envelope biosynthesis and degradation of surface polysaccharides and Lipopolysaccharides; Cellular processes: pathogenesis 4. Cell envelope: biosynthesis and degradation of murine sacculus and peptidoglycan 5. Cellular processes: pathogenesis 6. Cellular processes: toxin production and resistance; Cellular processes: pathogenesis 7. Unclassified: role category not yet assigned 8. Viral function: general 9. Cell envelope; cellular process – pathogenesis cellular process: cell adhesion 10. Cellular processes toxin production and resistance; Fatty acid and phospholipid metabolism: degradation 11. Cell envelope biosynthesis and degradation of surface polysaccharides and Lipopolysaccharides 12. Unclassified – role category not yet assigned 13. protein fate: Degradation of proteins, peptides and glycopeptides 14. Transport and binding proteins: Cations and iron carrying compounds; Cellular processes: pathogenesis; cellular processes:cell adhesion 15. protein fate: Degradation of proteins, peptides and glycopeptides; Cellular processes: pathogenesis 16. protein fate: Degradation of proteins, peptides and glycopeptides