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Chemokines and chemokine receptors axis can promote oncogenenic and cellular transformation. |
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They act as autocrine growth factors and increase clonal proliferation and tumor angiogenesis mediated by chemokine receptors. |
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They induce production of matrix metalloproteineases in malignant cells, thereby enhancing local invasive potential and metastasis. |
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Targeting chemokines and chemokine receptors in cancer-related inflammation and underlying mechanisms of chemokine action in PC facilitate the
development of novel therapies in the future. |