Chemokines and chemokine receptors axis can promote oncogenenic and cellular transformation.
They act as autocrine growth factors and increase clonal proliferation and tumor angiogenesis mediated by chemokine receptors.
They induce production of matrix metalloproteineases in malignant cells, thereby enhancing local invasive potential and metastasis.
Targeting chemokines and chemokine receptors in cancer-related inflammation and underlying mechanisms of chemokine action in PC facilitate the development of novel therapies in the future.
Table 1: Overview of Chemokines and Chemokine Receptors in Prostate Cancer.