Groups

Power of cardiac contractility (gm)

Heart rate (bpm)

control saline

3.778±0.7104

326.2±18.59

control carvedilol

2.579±0.4133

231.3±19.04

control nebivolol

2.658±0.3995

235.7±14.94

doxorubicin alone*

1.433±0.2861

75.33±12.09

dox + carvedilol†

2.170±0.2445

258.5±28.06

dox + nebivolol‡§

2.071±0.2263

250.3±29.93

*All measures of dox alone group was significantly different compared to control groups p<0.0001 † Cardiac contractility and heart rate were significantly different in dox-carvedilol treated group compared dox alone group p= 0.0001 & <0.0001 respectively ‡ dox–nebivolol treated group showed significant difference in cardiac contractility and heart rate compared to dox alone group p =0.0002 &<0.0001 respectively § No significant difference between measures of dox-nebivolol and dox-carvedilol treated groups p>0.05
Table 2: Cardio dynamic Measurements in Langendorff-perfused rat hearts. Data are presented as mean S.D. (n=8).