**Figure 5:** CaneCPI-4 reduces tumor cell development *in vivo*. Tumor cells (5x10^{4}) were injected subcutaneously in C57Bl/6 male (A and B) or female (C and D) mice
in the presence of Cane-CPI-4 (open circles), or PBS (control, closed circle). The tumor volume was measured every 2-3 days and the animals were sacrificed at a
maximum volume of 3cm^{3}. (A and C) Survival plots. (B and D) Tumor volume of individual animals. Statistical analysis of survivals was performed using Kaplan-Meier
test and p value comparing to control is shown in the Figure. Statistical analysis of survivals was performed using Kaplan-Meier test and p value in comparison with
the control is shown. |