|
Factor |
Number of
Patients1(n=212) |
3-Yrs Recurrence-Free |
5-Yrs Disease-Free Survival |
| % (95% CI) |
P Value2 |
% (95% CI) |
P Value |
Race |
|
|
0.8354 |
|
0.7082 |
| Black |
4 |
NA3 |
|
NA3 |
|
| White |
208 |
88 (83- 92) |
|
98 (96- 100) |
|
Age at diagnosis (years) |
|
|
0.8123 |
|
0.1935 |
| 60-70 |
104 |
85 (78- 92) |
|
NA3 |
|
| <=60 |
86 |
89 (83- 96) |
|
97 (93-100) |
|
| >70 |
22 |
81 (65- 98) |
|
NA3 |
|
Pre-prostatectomy PSA (ng/ml) |
|
|
0.0434 |
|
0.6713 |
| 4-10 |
113 |
88 (82- 94) |
|
97 (93- 100) |
|
| <4 |
22 |
NA3 |
|
NA3 |
|
| >10 |
43 |
84 (72- 95) |
|
96 (87- 100) |
|
Gleason score |
|
|
<0.001 |
|
<0.001 |
| 2-6 |
130 |
94 (89- 98) |
|
NA3 |
|
| 7 |
70 |
77 (67- 87) |
|
98 (93- 100) |
|
| 8-10 |
12 |
67 (40- 93) |
|
71 (43- 100) |
|
Surgical margin |
|
|
<0.001 |
|
0.3690 |
| Negative |
133 |
95 (91- 98) |
|
99 (96- 100) |
|
| Positive |
78 |
74 (64- 84) |
|
95 (90- 100) |
|
Extracapsular extension |
|
|
<0.001 |
|
0.2664 |
| Negative |
125 |
93 (88- 97) |
|
99 (96- 100) |
|
| Positive |
67 |
76 (65- 86) |
|
94 (88- 100) |
|
Disease Stage |
|
|
<0.001 |
|
0.1248 |
| Localized (T1) |
8 |
71 (38-100) |
|
NA3 |
|
| Localized (T2) |
134 |
94 (90- 98) |
|
99 (96- 100) |
|
| Localized (T3) |
57 |
71 (59- 83) |
|
95 (89- 100) |
|
AURKA SNP rs1468055 |
|
|
0.7213 |
|
0.3282 |
| A/A |
17 |
76 (57- 100) |
|
NA3 |
|
| A/C |
53 |
84 (74- 94) |
|
97 (91- 100) |
|
| C/C |
124 |
88 (83- 94) |
|
98 (95- 100) |
|
AURKA SNP rs8117896 |
|
|
0.5140 |
|
0.1909 |
| C/C |
70 |
87 (79- 85) |
|
96 (91- 100) |
|
| C/T |
42 |
82 (70- 94) |
|
NA3 |
|
| T/T |
34 |
88 (77- 99) |
|
NA3 |
|
AURKA SNP rs2064863 |
|
|
0.0714 |
|
0.4111 |
| G/G |
74 |
83 (75- 92) |
|
97 (92- 100) |
|
| G/T |
83 |
89 (82- 96) |
|
97 (92- 100) |
|
| T/T |
43 |
88 (78- 98) |
|
NA3 |
|
AURKA SNP rs1468056 |
|
|
0.4731 |
|
0.5014 |
| C/C |
29 |
73 (55- 90) |
|
NA3 |
|
| C/G |
53 |
89 (80- 97) |
|
97 (92- 100) |
|
| G/G |
74 |
90 (83- 97) |
|
NA3 |
|
1Analysis were limited to patients for whom data were available.
2P values for each factor were calculated by the log-rank test.
3Unable to calculate because all recurrence or death events occurred before 3-y or 5-y, respectively. |