Study Treatment Period (year from- to) Dose/ delivery of IMRT IMRT/ non IMRT: No of Patients Primary in oropharnx IMRT/non IMRT Type of Study Parotid functional Imaging done? Salivary output measurements? Questionnaire based or rated xerostomia evaluation? Salivary function benefit with parotid sparing?
Nutting et al. [7] 2003-2007 60-65 Gy in 30 fr, Linac 47 47 40 40 Randomized control trial No No Yes Yes
van Rij et al. [8] 1999-2003 ≥ 60 Gy/ Linear Accelerator (Linac) based 75 87 37 45 Retrospective case-control No No Yes Yes
Rudat et.al.[9] 2000-2005 ≥ 50 Gy/ Linac based 31 69 26 13 Prospective Cohort study Yes No Yes Yes
Dijkema et al. [10] 1996-2007 ≥ 66 Gy Linac based 64 157 48 28 Prospective Cohort study No Yes (cup) No No
Ortholan et al. [11] 2001-2004 > 50 Gy Linac based 24 20 * 35* Prospective Cohort study No Yes (parafilm chewing) No Yes
Chao et al. [12] 1970-1999 55.1-72 Gy Segmental Tomotherapy 26 404 26 404 Prospective cohort for patients after 1996µ No No Yes Yes
Daly et al. [13] 2000-2005 60-66 Gy Linac 29↑ 75 ** ** Retrospective case control No No Yes Yes
Saarilahti et al. [14] 2000-2002 56-72 Gy Linac 17 0 11 0 Prospective Cohort study No Yes (paraffin wax chewing) Yes Yes
Parliamen et al. [15] 2000-2002 60-70 Gy Linac 23 0 3 0 Prospective Cohort study No Yes (spitting ) Yes Yes
Marzi et al. [16] 2003∞ 60-70 Gy 59 0 9 0 Prospective Cohort study No Yes (spitting) Yes Yes
Eisbruch et al. [17] 1994- 2000 56-70 Gy Linac 132± 0 56 0 Prospective Cohort study No Yes (cup) Yes Yes
Hodge et al. [18] 1995-2005 65.1- 70.4 Gy Linac 52 143 52 143 Retrospective case control No No Yes No
Lee et al. [19] 1998-2004 70-72 Gy Linac 41 71 41 71 Retrospective case control No No Yes Yes
Rusthoven et al. [20] 1998-2007 66-70 Gy Linac 32 55 32 55 Retrospective case control No No Yes Yes
Vergeer et al. [21] 1999- 2004 56-70 Gy 91 150 34 46 Prospective Cohort study No No Yes Yes
Huang et al. [22] 2000- 2004 70 Gy Linac 71 0 71 0 Audit No No Yes Yes
Anand et al. [23] 2003-2004 66-70 Gy Linac 19 0 7 0 Prospective Cohort study Yes No Yes Yes
Lee et al. [24] 2003- 2004 60- 64.8 Gy Linac 34 0 5 0 Prospective Cohort study No Yes (spitting) Yes Yes
Pacholke et al. [25] 1996-2002 > 50 Gy Linac 27 183 24 78 Retrospective case control No No Yes Yes
Setton et al. [26] 1998-2009 66-70 Gy by conventional fr, linac 442 0 442 0 Prospective Cohort study No No Yes Yes
Dirix et al. [27] 2006-2008 72 Gy by Linac 42 0 12 0 Prospective Cohort study No No No Yes
Stock et al. [28] 2007-2009 66-70 Gy by conventional fr, linac 46 0 46 0 Prospective Cohort study No Yes No Yes
* break down of IMRT and non IMRT for oropharynx, not available. ↑ Total 69 patients with IMRT given questionnaire, 29 responded. ** Breakdown by site not available. ± Patients had parotid sparing IMRT or conformal parotid sparing techniques. μ Data was collected retrospectively for patients treated before 1996. IMRT patients recruited only after 1996. ∞ Date of last recruited patient not given.
Table 1: Studies reporting on parotid salivary gland sparing.