Figure 5: Effect of co-administration of mitomycin C and cisplatin with or without the administration of B.aristata on respiratory chain enzymes. of liver mitochondria. The animals were divided into four groups of six animals each. Group-1, received saline, group 2, received a single dose of mitomycin C (2 mg/ kg body weight, i.p) and cisplatin (12 mg/kg body weight, i.p). Rats were sacrificed 48 h after the administration of drugs. Group-3, received alcoholic extract of B.aristata (10 mg/100 g body weight, oral) for three days. Group-4 received alcoholic extract of B.aristata (10 mg/100 g body weight, oral) for three days, followed by single dose of mitomycin C (2 mg/kg body weight, i.p) and cisplatin (12 mg/kg body weight, i.p). Rats were sacrificed 48 h after the administration of drugs. NADH: cytochrome c reductase: 20 g of mitochondrial protein was used for each assay. Activity is expressed as n moles of cytochrome c reduced /min/ mg protein. Results are expressed relative to control which is taken as 100. The control value was 254+24. Succinate:cytochrome c reductase: 20 g of mitochondrial protein was used for each assay. Activity was expressed as n moles of cytochrome c reduced /min/ mg protein. Results are expressed relative to control which is taken as 100. The control value was 49+6.4. Cytochrome c oxidase: 1 g of mitochondrial protein was used for each assay. Reduced cytochrome c was used for each assay. Activity was expressed as n moles of cytochrome c reduced / min/ mg protein. Results are expressed relative to control which was taken as 100. The control value is 1138+134. Values are Mean SD for at least 13 animals. *p<0.05, **p<0.01 and ***p< 0.001.