Figure 6: Effect of co-administration of mitomycin C and cisplatin with or without the administration of B.aristata on respiratory chain enzymes.of kidney mitochondria. The animals were divided into four groups of six animals each. Group-1, received saline, group- 2, received a single dose of mitomycin C (2 mg/kg body weight, i.p.) and cisplatin (12 mg/kg body weight, i.p). Rats were sacrificed 48 h after the administration of drugs. Group 3, received alcoholic extract of B.aristata (10 mg/100 g body weight, oral) for three days. Group- 4 received alcoholic extract of B.aristata (10 mg/100 g body weight, oral) for three days, followed by single dose of mitomycin C (2 mg/kg body weight, i.p ) and cisplatin (12 mg/kg body weight, i.p). Rats were sacrificed 48 h after the administration of drugs. NADH: cytochrome c reductase: 20 g of mitochondrial protein was used for each assay. Activity is expressed as n moles of cytochrome c reduced /min/ mg protein. Results are expressed relative to control which was taken as 100. The control value was 262+13. Succinate:cytochrome c reductase: 20g of mitochondrial protein was used for each assay. Activity is expressed as n moles of cytochrome c reduced /min/ mg protein. Results are expressed relative to control which was taken as 100. The control value is 33+4.0. Cytochrome c oxidase: 1 g of mitochondrial protein was used for each assay. Reduced cytochrome c was used for each assay. Activity was expressed as n moles of cytochrome c reduced / min/ mg protein. Results were expressed relative to control which was taken as 100. The control value is 884+86. Values are Mean SD for at least 13 animals. *p<0.05, **p<0.01, and ***p<0.001.