Figure 12: The p53 pathway [49]. ATM, ataxia–telangiectasia mutated; BAX, BCL-2-associated X; HIPK2, homeodomain-interacting protein kinase 2; JNK, Jun N-terminal kinase; KAT5, K (lysine) acetyl transferase 5; MLH1, MutL protein homologue 1; PRMT5, protein arginine methyl transferase 5; SESN1, sestrin 1; SMYD2, SET and MYND domain-containing 2.