Figure 1: Scheme of modulated electrohyperthermia (mEHT) treatment (AB) and its hypothetical effect on HT29 colorectal cancer xenografts of Balb/c (nu/nu) mice (C-F). A) Parameters of the electric field and tumor temperature between 41-42°C during treatment are monitored by computer software. B) Thermal probes and electrode cooling of the treated right side. C-E) The electric field (red lines) is concentrated in the tumor implant (violet lump) between the condenser electrodes but cannot pass through cell membranes. F) However, it alternates by 13.56 MHz between endpoints 1 and 2 and can interact with ions and bipolar molecular groups (non-thermal effect) resulting in their rotation (curved arrows), which can also generate heat (thermal effect).