Figure 7: In vivo drug delivery of combination therapy encapsulated into tNPs. Mice bearing experimentally metastatic A549Luc tumors were treated either with tNP-Dox, tNP-IMD-0354 or tNP-Dox-IMD-0354. Tumor burden was measured by in vivo non-invasive imaging of A549Luc cells expressing firefly luciferase after intraperitoneal luciferin injection. Tumor bioluminescence intensity was plotted in pseudocolor over back/white photographs (A) and quantified as total flux in photons/ seconds. Data are shown as mean ± SEM. *P-value < 0.05.