Figure 4: Comparisons of amino acid sequence of mGHR106 Mab and three different hGHR106 Mabs in the Fab regions of GHR106 Mabs. The FR/CDR domains are defined along with the deduced sequence for comparisons(A) Induced apoptosis on treated cultured OC-3-VGH cancer cells by normal mouse IgG (NmIgG) (Lane 1), normal human IgG (NhIgG) (Lane 2), mRP215 (Lane 3), and hRP215 (Lane 4) for 24 hour incubation. Open and solid column represent 1μg/ml and 10 µg/ml, respectively of the ligands used for the apoptosis assay. (B) Induced apoptosis on treated cultured OC- 3-VGH cancer cells by normal mouse IgG (NmIgG) (Lane 1), normal human IgG (NhIgG) (Lane 2), mGHR106 (Lane 3), and hGHR106 (Lane 4) (10 µg/ ml). Solid and open column represent the corresponding data obtained for 24 hour or 48 hour incubation, respectively. Statistical significance at *: p<0.01 and **: p<0.001, see Reference [23,27].