Authors & Year N cases Type of study Age (yrs) Good PS (%) Debulk surg (%) Alkyl (%) MGMT assayed (%) MGMT meth (%) Deaths (%)
3 mos 6 mos
MGMT methylation prognostic/predictive
Balañà et al.[21] 70 reta,b 64 88.6 85.7 98.6 100 38.6 5.7 17.1
Brandes et al.[22] 103 triala,b 53 92 99 100 100 35 0 1.9
Cao et al.[23] 73 reta 55 54.2 91.6 100 100 60.3 1.4 8.2
Crinière et al.[24] 77 reta 58 63 NA 100 100 58.4 1.3 6.5
Dunn et al.[20] 109 reta,b 55 84 76 100 100 53.2 3.7 15.6
Ellingson et al.[25] 358 reta 56.4 NAc NA NA 100 36 1.1 5
Etcheverry et al.[26] 50 prosa 57.5 NAd NA 100 100 60 8 18
Felsberg et al.[27] 66 prosa,b 56 82 100 100 100 39.4 0 1.5
Gilbert et al.[5] 760 triala,b NAe 100 97 100 100 32.1 0.8 6.7
Hegi et al.[3] 106 triala,b 56 87.3 83.8 100 100 43.4 1.9 10.4
Karayan-Tapon et al.[28] 81 reta 61 64.2 NA 100 100 67.9 0 2.5
Lai et al.[29] 141 trial+ reta,b 58 96.1 86.2 100 100 40.4 0.7 7.1
Lakomy et al.[30] 38 reta,b 53 95 100 100 100 31.6 2.6 7.9
Metellus et al.[31] 61 prosa,b 59 34.4 100 100 100 37.7 0 1.6
Morandi et al.[32] 159 reta 57 100 NA 100 100 44 1.9 6.3
Motomura et al.[33] 68 reta 55 66.2 NA 100 100 33.8 1.5 2.9
Stupp et al.[34] 45 triala,b 57 92 83 100 100 51.1 2.2 8.9
Weiler et al.[35] 41 trialb 56 100 90 100 95.1 41 0 2.4
Weller et al.[36] 185 prosa,b 61.5 84 90 100 100 43.8 2.7 7
MGMT methylation no prognostic/predictive
Clarke et al.[10] 85 trial 56.3 73 78 100 56.5 18.8 0 4.7
Costa et al.[11] 80 ret 56 53.3 90 100 100 47.5 6.3 23.8
El Hindyet al.[12] 160 ret 58 NA 59.4 37.5 66.3 18.9 13.8 31.9
Iliadiset al.[13] 65 pros 59 90 90.8 100 35.4 43.5 1.5 7.7
Lam&Chambers et al.[14] 101 ret 56.5 47 68 100 100 49.5 3 15.8
Martinez et al.[15] 46 ret 60.6 NA NA 100 100 32.6 2.2 8.7
Mellai et al.[9] 67 ret 60.3 NA 100 35 100 29.9 13.4 31.3
Schaich et al.[16] 63 ret 63 84 NA 100 100 34.9 0 4.8
Tang et al.[17] 79 ret NA 57 100 100 100 32.9 5.1 15.2
a, MGMT prognostic for longer overall survival; b, MGMT predictive for longer progression-free survival when treated with alkylating drugs; c, mean KPS 72.4; d, median KPS 78.6. Alkyl, treated with alkylating drugs; e, 26.8 of patients with age < 50 yrs. Debulk surg: debulking surgery; Meth: Methylated; MGMT: O6-Methylguanine DNAMethyltransferase; NA: Not Available; Pros: Prospective; PS: Performance Status; Ret: Retrospective
Table 1: Systematic review of studies analyzing the relationship between MGMT methylation and prognosis in glioblastoma patients.