Authors & Year N cases Deaths at 3 months (%)
whole cohort methylated pts unmethylated pts
MGMT methylation prognostic/predictive
Balañàet al.[21] 70 5.7 0 9.3
Brandes et al.[22] 103 0 0 0
Cao et al.[23] 73 1.4 0 3.4
Crinière et al.[24] 77 1.3 0 3.1
Dunn et al.[20] 109 3.7 3.4 3.9
Ellingsonet al.[25] 358 1.1 0 1.8
Etcheverryet al.[26] 50 8 6.7 10
Felsberg et al.[27] 66 0 0 0
Gilbert et al.[5] 760 0.8 0.8 0.8
Hegi et al.[3] 106 1.9 2.2 1.7
Karayan-Tapon et al.[28] 81 0 0 0
Lai et al.[29] 141 0.7 0 1.2
Lakomyet al.[30] 38 2.6 0 3.8
Metellus et al.[31] 61 0 0 0
Morandi et al.[32] 159 1.9 0 3.4
Motomura et al.[33] 68 1.5 0 2.2
Stupp et al.[34] 45 2.2 0 4.5
Weiler et al.[35] 41 0 0 0
Weller et al.[36] 185 2.7 1.2 3.8
MGMT methylation no prognostic/predictive
Clarke et al.[10] 85 0 0 0
Costa et al.[11] 80 6.3 5.3 7.1
El Hindyet al.[12] 160 13.8 NA NA
Iliadiset al.[13] 65 1.5 NA NA
Lam&Chambers[14] 101 3 4 2
Martinez et al.[15] 46 2.2 6.7 0
Mellai et al.[9] 67 13.4 10 14.9
Schaich et al.[16] 63 0 0 0
Tang et al.[17] 79 5.1 3.8 5.7
MGMT: O6-methylguanine DNA-methyltransferase; pts: patients
Table 5: Deaths at 3 months according to MGMT status in reviewed studies.