Parameters Univariate analysis Multivariate analysis
HR 95% CI p-value HR 95% CI p-value
Age, years ≤60 vs >60 3.84 2.06-22.7 0.001 0.46 0.09-2.17 0.32
Type of first line-chemotherapy Single agent vs combination Antracyclines vs Taxanes vs other 1.39 0.85 0.57-3.43 0.39-6.71 0.4 0.93 -    
Ki-67 ≤ 20% vs >20% 2.21 1.37-6.51 0.0009 2.37 1.11-5.07 0.02
Necrosis negative vs positive 0.70 0.2-2.07 0.47 -    
Lympho-vascular invasion negative vs positive 0.42 0.12-0.97 0.04 1.19 0.31-4.55 0.79
Visceral disease yes vs not 0.17 0.11-0.69 0.006 3.84 0.7-21.15 0.12
e-cadherin negative vs positive 0.50 0.20-1.38 0.19 -    
Aldh1 negative vs positive 0.77 0.29-1.93 0.55 -    
CK5 or CK 17 negative vs positive 0.57 0.19-1.44 0.21 -    
AR negative vs positive 2.88 1.32-9.43 0.01 2.21 0.98-2.55 0.05
Table 3: Univariate and multivariate Cox regression analysis of factors associated with overall-survival in advanced triple negative breast cancer.