Pt LEC dose (μg/kg) Tumora Stage Time from dx to LEC treatment Previous therapyb Treatment following LEC and to ceranibc Survival post-LEC (months) Status 1 17.8 scc III 1 yr chemo - 1.2 euthanized 2 21.2 hepatic sarcoma III 1 wk - - 2.8 euthanized 3 22.2 digital melanoma III 8 mo chemo, toceranib, vax carboplatin, temozolamide 4.7 euthanized 4 22.5 soft tissue sarcoma Ib 5 mo XRT, chemo, piroxicam - 2.1 euthanized 5 25.0 oral melanoma IV 2 mo - - 0.3 died 6 33.3 soft tissue sarcoma IIa 7 mo chemo CTX 4.7 died 7 40.0 hcc III 1 mo chemo mitoxantrone 9.9 euthanized 8 42.5 oral melanoma IV 7 mo chemo, vax CTX 9.5 euthanized 9 44.1 hcc III 7 mo surgery - 18.2 euthanized 10 45.0 oral melanoma IV 14 mo chemo, vax XRT 3.8 died 11 67.0 scc II 5 mo XRT - 0.5 euthanized 12 67.5 scc I 3 mo chemo, piroxicam bleomyocin 31.1 alive 13 69.0 soft tissue sarcoma Ib 1 wk - surgery, XRT 2.5 alive 14 70.0 digital melanoma III 8 mo surgery, XRT - 3.0 euthanized 15 70.0 scc III 1 mo piroxicam - 3.7 alive 16 82.8 oral melanoma III 5 mo chemo, toceranib, vax - 1.7 died 17 103 osteosarcoma IIb 4 mo chemo - 5.4 euthanized 18 133 apocrine gland carcinoma III 7 mo XRT, chemo, toceranib XRT 17.9 died 19 211 histiocytic sarcoma IIIb 9 mo chemo prednisone 2.2 euthanized 20 330 oral melanoma IV 1 mo XRT - 2.1 euthanized 21 524 soft tissue sarcoma IIb 1 yr surgery prednisone 1.1 euthanized 22 540 soft tissue sarcoma Ib 5 mo surgery, XRT doxorubicin 6.3 alive 23 540 soft tissue sarcoma, mast cell tumor IIb, III 15 mo, 5 yr surgery, chemo, toceranib - 0.7 euthanized ascc = squamous cell carcinoma, hcc = hepatocellular carcinoma bXRT = radiation, chemo = chemotherapy, vax = vaccine (ONCEPT®) cCTX = cyclophosphamide

Table 1: Patient characteristics.