Parameter Genotype/Allele Study n % Control n % p- value OR 95% CI Male Pro/Pro 05         14.6 08         12.9 0.7 1.2 0.5-3.0 Arg/Pro 18         43.9 18         29.0 .12 2.0 1.7-6.0 Arg/Arg 18         41.4 36         58.0 Reference     Pro/Pro +Pro/Arga 24         58.5 26         41.9 0.1 0.6 0.3-2.6 Pro allele 30         36.5 34         27.8 0.1 1.5 1.1-4.0 Arg allele 52         63.5 90         73.7 Reference     Female Pro/Pro 17         34.6 14         22.0 0.04 2.5 1.1-4.4 Arg/Pro 22         44.8 33         48.5 0.4 0.6 0.3-2.8 Arg/Arg 10         20.4 21         29.4 Reference     Pro/Pro +Pro/Arga 39         79.5 47         69.1 0.2 0.6 0.4-2.9 Pro allele 56         57.1 51         37.5 0.01 1.9 1.3-3.0 Arg allele 42        48.8 75         55.1 Reference     Low Grade Tumor Pro/Pro 09        16.9 23        17.7 0.764 1.15 0.46-.88 Arg/Pro 25         47.2 51         39.2 0.307 1.44 0.71.-91 Arg/Arg 19         35.8 56         43.1 Reference -    Pro/Pro +Pro/Arga 34         64.2 74         56.9 0.367 1.35 0.69-2.61 Pro allele 43         40.6 97         42.2 0.516 1.15 0.72-0.82 Arg allele 63         59.4 163       57.8 Reference -  - High Grade Tumor Pro/Pro 13         35.1 23         17.7 0.009 3.51 1.34-9.19 Arg/Pro 15         40.5 51         39.2 0.189 1.83 0.75-4.45 Arg/Arg 9         24.3 56         43.1 Reference - - Pro/Pro +Pro/Arg a 28       75.7 74         56.9 0.039 2.35 1.03-5.36 Pro allele 41       55.4 97         42.2 0.005 2.09 1.23-3.52 Arg allele 33       44.6 163       57.8  Ref. -  - Neuroepithelial Tissue Tumor Pro/Pro 13       37.1 23        17.7 0.009 3.52 1.349.2 Arg/Pro 13        37.1 51        39.2 0.329 1.58 0.643.94 Arg/Arg 9         25.7 56         43.1 Reference  - - Pro/Pro +Pro/Arga 26       74.2 74         56.9 0.062 2.19 0.954.95 Pro allele 39       55.7 97         42.2 0.005 2.11 1.233.59   Arg allele 31       44.3 163       57.8 Reference -  - Meningeal Tumor Pro/Pro 2          7.4 23         17.7 0.249 0.41 0.10-1.77 Arg/Pro 13        48.1 51         39.2 0.696 1.19 0.50-2.80 Arg/Arg 12        44.4 56         43.1 Reference  - - Pro/Pro +Pro/Arga 15       55.5 74         56.9 0.896 0.95 0.41-2.14 Pro allele 17        31.5 97         42.2 0.418 0.77 0.41-1.44 Arg allele 37        68.5 163       57.8 Reference  - - Malignant Tumor Pro/Pro 16        37.2 23         17.7 0.003 3.89 1.56-9.71 Arg/Pro 17        39.5 51         39.2 0.155 1.86 0.79-4.38 Arg/Arg 10        23.3 56         43.1 Ref.      Pro/Pro +Pro/Arga 33        76.7 74         56.9 0.020 2.50 1.14-5.47 Pro allele 49        57.0 97         42.2 0.001 2.23 1.34 Arg allele 37        43.0 163       57.8 Reference     Benign Tumor Pro/Pro 6          12.7 23         17.7 0.695 0.81 0.29-3.67 Arg/Pro 23        48.9 51         39.2 0.358 1.40 0.68 Arg/Arg 18        38.3 56         43.1 Reference     Pro/Pro +Pro/Arg a 29        61.7 74         56.9 0.569 1.22 0.612.25 Pro allele 35        37.2 97         42.2 0.990 0.99 0.61-2.87 Arg allele 59        62.7 163       57.8 Reference

Table 3: Association between TP53 codon 72 genotypes and clinico-pathologic characteristics.