Figure 4: Biopsy specimens from the gastric tumor. The findings are consistent with the presence of poorly differentiated, diffuse type signet-cell containing adenocarcinoma. [A] Section demonstrating diffusely infiltrating tumor-cell complexes within differentiated glands, [B] Section showing typical appearance of diffuse type gastric carcinoma consisting of loose, mucin producing cells within large pools of mucus (both hematoxylin and eosin stain) [C] Close up showing signet cells characterized by abundant cytoplasmic mucin that displaces the nucleus to the periphery (arrows, 100X periodic acid-Schiff stain, 400X).