Cisplatin based chemotherapy
(n=298)
Carboplatin oroxaliplatin basedchemotherapy(n=357)
Non-platinum based chemotherapy (n=495)
Total (n=1150)
Hyponatremia
42 (14.1%)
25 (7%)
38 (7.7%)
105 (9.1%)
SIADH
26 (8.7%)
13 (3.6%)
29 (5.9%)
68 (5.9%)
Mean serum Na
(mmol/L)
128.9
129.1
129.5
129.2
Range
(123-133)
(126-133)
(127-133)
(123-133)
Grade of hyponatremia
Mild (130-135)
12 (4%)
8 (2.2%)
19 (3.8%)
39 (3.4%)
Moderate (125-130)
29 (9.7%)
17 (4.8%)
19 (3.8%)
65 (5.7%)
Severe (<125)
1 (0.3%)
None
None
1 (0.09%)
Hyponatremia fulfilling SIADH
26/42 (62%)
13/25 (52%)
29/38 (76%)
68/105 (65%)
Table 4:
Details of hyponatremia among patients receiving different chemotherapy regimens.
