Drug p110α p110β p110δ p110γ mTOR Reference
GDC-0941 3 33 3 75   [89,90]
PX-866 6 >300 uM 3 9   [91]
BKM120 52 166 116 262 2866 [56]
XL147 39 383 36 23 >15000 [92]
ZSTK474 16 44 5 49   [93]
CAL-101 >100 uM 1820 uM 70 1240   [94]
CH5132799 14 120 500 36 1600 [62]
PF-04691502 1.8 2.1 1.6 1.9 16 [64]
PF- 05212384 0.4 6 8 6 1 [65]
GSK2126458 0.019 0.13 0.024 0.06 0.18 [95]
XL765 39 113 43 8 157 [96]
BEZ235 4 75 7 5 21 [97]
SF1126 356 736 3225 1774 1060 [98]
GDC-0980 5 27 7 14 17 [99]
Table 2: Comparison of kinase inhibition profile of various PI3K inhibitors (IC50 in nM).