Dutasteride (N = 3 305) Placebo (N = 3 424) Mean Differencea Wilcoxon Rank-Sum
Resource Mean (SD) b Mean (SD)b Estimate 95% CI P Value
Total $1 877 ($7 098) $3 177 ($12 707) $1 300.40 $806.15-$1 794.66 < 0.001
Concomitant Medications $1 028 ($3 078) $1 004 ($2 666) –$24.28 –$161.75 to $113.19 0.005
Alpha-blockers $818 ($2 110) $830 ($2 092) $11.28 –$89.15 to $111.71 0.004
Health Care Visits          
Surgical procedures $539 ($5 358) $1 576 ($10 164) $1 036.66 $646.34 to $1 426.97 < 0.001
Nonsurgical procedures $0 ($4) $6 ($311) $5.61 –$4.99 to $16.21 0.104
Unscheduled biopsies $23 ($74) $32 ($86) $9.16 $5.32 to $12.99 < 0.001
UTI $69 ($965) $150 ($2 085) $81.22 $3.12 to $159.32 < 0.001
AUR $115 ($1 802) $318 ($2 707) $203.55 $93.24 to $313.85 < 0.001
Macroscopic hematuria $96 ($1 501) $91 ($1 189) –$5.30 –$69.89 to $59.29 0.001
Macroscopic hematospermia $7 ($352) $0 ($4) –$6.21 –$18.01 to $5.58 0.336
AUR = acute urinary retention; CI = confidence interval; SD = standard deviation; UTI = urinary tract infection. a Mean difference = placebo costs – dutasteride costs. b Median cost was zero for all resource use categories; inter-quartile range was zero for all resource use categories except concomitant medications.
Table 4: Summary of Health Care Costs by Treatment Group.