| |
Dutasteride
(N = 3 305) |
Placebo
(N = 3 424) |
Mean Differencea |
Wilcoxon Rank-Sum |
| Resource |
Mean (SD) b |
Mean (SD)b |
Estimate |
95% CI |
P Value |
| Total |
$1 877 ($7 098) |
$3 177 ($12 707) |
$1 300.40 |
$806.15-$1 794.66 |
< 0.001 |
| Concomitant Medications |
$1 028 ($3 078) |
$1 004 ($2 666) |
–$24.28 |
–$161.75 to $113.19 |
0.005 |
| Alpha-blockers |
$818 ($2 110) |
$830 ($2 092) |
$11.28 |
–$89.15 to $111.71 |
0.004 |
| Health Care Visits |
|
|
|
|
|
| Surgical procedures |
$539 ($5 358) |
$1 576 ($10 164) |
$1 036.66 |
$646.34 to $1 426.97 |
< 0.001 |
| Nonsurgical procedures |
$0 ($4) |
$6 ($311) |
$5.61 |
–$4.99 to $16.21 |
0.104 |
| Unscheduled biopsies |
$23 ($74) |
$32 ($86) |
$9.16 |
$5.32 to $12.99 |
< 0.001 |
| UTI |
$69 ($965) |
$150 ($2 085) |
$81.22 |
$3.12 to $159.32 |
< 0.001 |
| AUR |
$115 ($1 802) |
$318 ($2 707) |
$203.55 |
$93.24 to $313.85 |
< 0.001 |
| Macroscopic hematuria |
$96 ($1 501) |
$91 ($1 189) |
–$5.30 |
–$69.89 to $59.29 |
0.001 |
| Macroscopic hematospermia |
$7 ($352) |
$0 ($4) |
–$6.21 |
–$18.01 to $5.58 |
0.336 |
AUR = acute urinary retention; CI = confidence interval; SD = standard deviation; UTI = urinary tract infection.
a Mean difference = placebo costs – dutasteride costs.
b Median cost was zero for all resource use categories; inter-quartile range was zero for all resource use categories except concomitant medications. |