Study Year Cohort Nº cases Intervention End Point RR Result
PHS (Gann) 1993 Healthy 22071 325 mg every other day vs. placebo CCR incidence 1.15 0.80-1.65 Negative
PHS (Stürmer) 1998 Healthy 22071 325 mg every other day vs. placebo CCR incidence 1.03 0.83-1.28 Negative
Cook et al. [10] 2004 Healthy 39876 100 mg every other day CCR incidence 0.97 0.77-1.24 Negative
Baron et al. [11] 2003 Prior adenoma 1121 81 mg vs. 325 mg daily vs. placebo Adenomas incidence 0.81 0.69-0.96 Positive for 81 mg arm
Sandler at al. [13] 2003 Prior CCR 635 325 mg daily vs. placebo Adenomas incidence 0.65 0.46-0.91 Positive
APPAC 2003 Prior adenoma 272 160 mg vs. 325 mg vs. placebo Adenomas incidence 0.73 0.52-1.04 Negative in global
Table 1: Aspirin trials in sporadic CRC.