| Study |
Year |
Cohort |
Nº cases |
Intervention |
End Point |
RR |
Result |
|
APPROVe |
2006 |
Prior adenoma |
2587 |
25 mg rofecoxib vs. placebo |
Adenoma
incidence |
0.76
0.69-0.83 |
Positive |
|
APC |
2006 |
Prior adenoma |
2035 |
200 mg bid vs. 400 mg bid vs. placebo |
Adenoma
incidence |
0.67
0.55 |
Positive for both doses |
|
PreSAP |
2006 |
Prior adenoma |
1561 |
400 mg once vs. placebo |
Adenoma
incidence |
0.64
0.56-0.75 |
Positive |
|