Figure 3: The ASncmtRNAs are down-regulated in CIN3 and ICC. A) ISH reveals expression of the SncmtRNA and down-regulation of the ASncmtRNAs in two specimens of CIN3. The hybridization signal of the SncmtRNA is on the basal and middle layer of the epithelium. B) The results show down-regulation of the ASncmtRNAs in two specimens of ICC. The hybridization signal of the SncmtRNA covers the complete tumor tissue as compare with H&E staining (40x).