Dose (mg/kg)
Gender
Period τ (h)
Mesor ± SEM (% of lethality)
Amplitude ± SD (% of lethality)
Acrophase ±SD (min)b
P a
4.9
5.4
6.0
Male
Female
12 24 12 24 12 24 12 24 12 24 12 24
61 ± 5 61 ± 5 40 ± 4 40 ± 4 60 ± 4 60 ± 5 60 ± 4 61 ± 4 69 ± 4 72 ± 4 66 ± 5 66 ± 5
18 ± 17 6 16 ± 15 7 26 ± 16 12 28 ± 15 14 20 ± 13 15 ± 14 25 ± 17 10
9.0 ± 120 14.6 9.6 ± 120 23.5 9.8 ± 74 16.4 10.4 ± 60 1.4 9.1 ± 79 14.0 ± 258 10.0 ± 82 1.7
0.0003 NS 0.0004 NS 0.0004 NS 0.0001 NS 0.001 0.003 0.001 NS
a From an F test of the rejection of the null amplitude hypothesis. bTime of maximum in fitted cosine function, in HALO. NS: Not significant
Table 1: Parameters of ultradian and circadian lethality in 2 week old mice
