Dose (mg/kg)
Gender
Period τ (h)
Mesor ± SEM (% of lethality)
Amplitude ± SD (% of lethality)
Acrophase ±SD (min)b
P a
6.0
6.6
Male
Female
12 24 12 24 12 24 12 24
28 ± 5 28 ± 5 25 ± 4 26 ± 4 44 ± 4 44 ± 4 36 ± 4 35 ± 4
10 15 ± 14 4 14 ± 13 4 20 ± 13 8 15 ± 14
11.9 21.4 ± 120 8.5 22.5 ± 120 0.5 20.9 ± 120 8.7 20.7 ± 120
NS 0.0004 NS 0.0003 NS 0.0005 NS 0.0003
a From an F test of the rejection of the null amplitude hypothesis. bTime of maximum in fitted cosine function, in HALO. NS: Not significant
Table 2: Parameters of ultradian and circadian lethality in 4 week old mice
