Dose (mg/kg)

Gender

Period τ (h)

Mesor ± SEM (% of lethality)

Amplitude ± SD (% of lethality)

Acrophase ±SD (min)b

P a

6.0

6.6

Male

Female

Male

Female

12 24 12 24 12 24 12 24

23 ± 4 25 ± 4 16 ± 3 15 ± 3  33 ± 4 32 ± 4 30 ± 4 30 ± 4

6 13 ± 12 6 12 ± 10 10 17 ± 13 10 15 ± 14

1.8 18.8 ± 120 5.9 17.3 ± 120 4.2 18.0 ± 120 4.8 18.7 ± 120

NS 0.0004 NS 0.0001 NS 0.0007 NS 0.0003

a From an F test of the rejection of the null amplitude hypothesis. bTime of maximum in fitted cosine function, in HALO. NS: Not significant
Table 3: Parameters of ultradian and circadian lethality in 8 week old mice