System Organ Class Dextran 40 Dextran 40, 100 mannitol Dextran 75
Cardiac disorder Bradycardia (6) Decreased heart Rhythm (1) Atrial fibrillation (1)
  Cardiac disorder (13) Tachycardia (6) Tachycardia (1)
  Palpitation (1) Heart race (1) Cardiac disorder (2)
  Tachycardia (28)    
Total 48 8 4
Eye disorders Conjuctivitis (2) NR NR
  Eye burning (2)    
  Pupil dilatation (1)    
Total 5 0 0
General disorders Chills (88) Chills (10) Injection site reaction (1)
  Dead (1) Temperature increased (6) Chills (2)
  Dizziness (1) Pain (1) Temperature increased (3)
  Temperature changes (79) Injection site reaction (1)  
  Head pressure (1) Fever (1)  
  Pain (5)    
  Hypotonie (3)    
  Incompability (1)    
  Lack of consciousness (2)    
Total 181 19 6
Gastrointestinal disorders Vomiting (42) Stomach pain (1) Nausea (2)
  Stomach pain (2) Nausea (3) Vomiting (1)
  Nausea (29) Vomiting (2)  
  Mouth blister (2)    
  Hyperstomie (1)    
  Diarrhea (4)    
Total 80 6 3
Infections and infestations Flu symptoms (1) NR Pyrogen reaction (1)
  Pyrogen reaction (2)    
Total 3 0 1
Investigations Blood pressure increased (10) Increased pulse (1) Decreased blood pressure (1)
  Pulse changes (3) Blood pressure changes (6) Hypertension (1)
Total 13 7 2
Immune system disorders Anaphylactic reaction/shock (25) Anaphylactic reaction/shock (4) Anaphylactic reaction/shock (11)
Total 25 4 11
Musculoskeletal disorders Muscle pain (24) Back pain (1)  NR
Total 24 1 0
Nervous system disorders Parasthesies (2) Headache (3) Convulsions (1)
  Headache (4) Restlessness (1)  
  Vertigo (1) Uterus contraction (1)  
  Restlessness (2)    
  Tingling (2)    
  Trembling (1)    
Total 12 5 1
Psychiatric disorders Psychiatric disorder (2) Anxiety (1) Anxiety (1)
Total 2 1 1
Renal and urinary disorders Kidney pain (3) Kidney pain (2)  NR
Total 3 2 0
Respiratory disorders Bronchospasm (74) Lung oedema (2) Difficulty breathing (11)
  Cough (3) Difficulty breathing (8)  
  Cyanosis (17) Cyanosis (2)  
  Lung oedema (7)    
Total 101 12 1
Skin and subcutaneous disorders Urticaria (22) Skin redness (3) Erythema (1)
  Rash (2) Urticaria (1) Hot flashes (1)
  Pruritus (26) Exanthem (5) Lip oedema (1)
  Swelling (3) Hot flashes (1) Rash (3)
  Erythem (5) Oedema (3)  
  Oedema (10)    
  Blister (8)    
  Hot flashes (1)    
  Exanthem (26)    
  Itching (5)    
Total 108 13 6
Vascular disorders Circulatory collaps/schock (39) Circulatory collaps/schock (4) NR
Total 39 4 0
Total ADRs (N) 645 82 46
Table 4: Characteristics of adverse drug reactions (N) reported for dextrans containing products reported from 1982 to 1990 in the German Democratic Republic (numbers in brackets).