Male Control 60mg/kg/day 200mg/kg/day 600mg/kg/day
Terminal body weights (g) 419±25 421±30 412±25 371±22**
Kidneys (g) 2.81±0.23 2.86±0.25 2.79±0.16 2.87±0.17
(%) 0.66±0.03 0.67±0.04 0.67±0.03 0.77±0.04**
Brain (g) 2.09±0.06 2.07±0.08 2.03±0.07 2.07±0.10
(%) 0.49±0.03 0.49±0.04 0.49±0.03 0.55±0.03**
Female Control 60mg/kg/day 200mg/kg/day 600mg/kg/day
Terminal body weights (g) 276±19 275±26 272±19 252±17*
Brain (g) 1.92±0.05 1.90±0.09 1.94±0.10 1.94±0.07
(%) 0.67±0.04 0.67±0.06 0.69±0.04 0.76±0.05**
* Significantly different from control at P<0.05. ** Significantly different from control at P<0.01. %: organ weight as a percentage of body weight
Table 3: Terminal body weights and abnormal organ weights (mean ± SD) in the TG 407.