Adverse Event M + D + C* Group (n=50) M + D + P* Group (n=50) p
Ataxia 4 1 n.s.
Skin rash 1 2 n.s.
Tachycardia 1 0 n.s.
Increased blood pressure 1 0 n.s.
Seizures 0 1 n.s.
p-amylase elevation 17 8 <.05
AST elevation 3 5 n.s.
ALT elevation 8 9 n.s.
GGT elevation 11 5 n.s.
GLDH elevation 4 6 n.s.
Sum 50 37 <.05
N.S.: Not Significant; M: Methadone; D: Diazepam; C: Carbamazepine; P: Placebo
Table 2: Frequency of Adverse Events (absolute numbers).