| Adverse Event |
M + D + C*
Group (n=50) |
M + D + P*
Group (n=50) |
p |
| Ataxia |
4 |
1 |
n.s. |
| Skin rash |
1 |
2 |
n.s. |
| Tachycardia |
1 |
0 |
n.s. |
| Increased blood pressure |
1 |
0 |
n.s. |
| Seizures |
0 |
1 |
n.s. |
| p-amylase elevation |
17 |
8 |
<.05 |
| AST elevation |
3 |
5 |
n.s. |
| ALT elevation |
8 |
9 |
n.s. |
| GGT elevation |
11 |
5 |
n.s. |
| GLDH elevation |
4 |
6 |
n.s. |
| Sum |
50 |
37 |
<.05 |
N.S.: Not Significant; M: Methadone; D: Diazepam; C: Carbamazepine; P: Placebo |
