parameters Groups/(dose) time（h） 0 4 8 12 24 48 72 96 Heart rate C 142.40 ± 29.50 138.20 ± 28.25 140.80 ± 26.29 130.00 ± 7.21 132.40 ± 19.46* 137.80 ± 13.60* 142.80 ± 17.81 132.80 ± 15.84 B 141.67 ± 22.46 156.33 ± 17.17 145.33 ± 24.12 148.00 ± 35.44 156.00 ± 23.15 148.00 ± 13.56 149.33 ± 23.31 148.67 ± 22.72 A 155.00 ± 19.00 144.83 ± 13.51 149.33 ± 20.18 147.67 ± 16.65 164.67 ± 18.67 167.33 ± 20.57 153.33 ± 18.48 140.00 ± 31.01 WBC C 22.81 ± 2.33 29.19 ± 2.26*# 38.51 ± 5.51*# 40.46 ± 4.70*# 22.80 ± 2.09 20.21 ± 0.84 19.15 ± 1.21 18.96 ± 1.54 B 21.7 ± 2.06 21.95 ± 1.59# 25.95 ± 1.77# 25.61 ± 2.633# 19.53 ± 2.37 17.61 ± 1.12 17.7 ± 1.39 16.98 ± 1.28 A 19.68 ± 2.00 21.81 ± 1.42 19.65 ± 2.34 20.21 ± 3.75 20.03 ± 4.31 18.85 ± 3.18 15.90 ± 1.95 15.88 ± 1.25 ALT (U/L) C 54.56 ± 15.06 104.08 ± 26.96**# 112.30 ± 25.68**# 116.14 ± 24.19**# 103.62 ± 17.60** 83.02 ± 20.64* 73.64 ± 22.79* 56.88 ± 24.54 B 55.16 ± 17.38 69.87 ± 22.56# 74.57 ± 24.70# 77.08 ± 26.36# 81.77 ± 38.17* 64.65 ± 29.26 51.05 ± 13.61 49.88 ± 14.57 A 55.05 ± 13.12 52.97 ± 13.53 52.17 ± 12.67 51.92 ± 9.28 43.41 ± 11.08 46.02 ± 13.33 45.93 ± 16.48 42.67 ± 15.64 AST (U/L) C 33.26 ± 7.35 214.67 ± 108.28** 488.33 ± 249.41** 413.40 ± 212.33** 210.85 ± 141.74* 65.67 ± 73.83 44.43 ± 48.32 22.75 ± 7.52 B 28.97 ± 6.90 168.08 ± 125.33* 327.02 ± 250.03* 292.02 ± 280.55** 140.33 ± 183.85 31.75 ± 21.06 19.80 ± 3.67 19.35 ± 3.06 A 32.53 ± 8.66 34.85 ± 9.97 35.28 ± 9.58 34.02 ± 6.06 22.02 ± 5.94 21.55 ± 5.40 20.07 ± 6.73 23.22 ± 6.86 TBIL (µmol/L) C 3.62 ± 0.50 3.47 ± 0.46 3.98 ± 1.17 3.98 ± 1.19 4.69 ± 1.34* 4.10 ± 0.61 3.67 ± 0.42# 3.80 ± 0.68 B 3.75 ± 0.76 3.37 ± 0.61 3.73 ± 0.73 3.73 ± 0.82 4.28 ± 1.01 4.42 ± 0.45* 4.35 ± 0.39*# 4.23 ± 0.27 A 3.53 ± 0.71 3.37 ± 0.36 3.67 ± 0.38 3.30 ± 0.60 3.26 ± 0.42 3.42 ± 0.65 3.76 ± 0.48 3.67 ± 0.29 CREA (µmol/L) C 122.85 ± 8.69 141.96 ± 9.30 138.88 ± 7.62 143.41 ± 8.41 168.95 ± 13.41* 157.10 ± 9.09 142.18 ± 4.31 136.18 ± 6.95 B 121.31 ± 4.77 127.99 ± 8.14 126.81 ± 8.44 139.54 ± 12.44 155.14 ± 12.50* 135.80 ± 9.22 120.19 ± 8.18 118.41 ± 7.12 A 124.68 ± 7.60 124.09 ± 5.166 129.37 ± 4.73 131.51 ± 4.54 120.34 ± 6.72 132.50 ± 6.41 131.98 ± 8.03 131.18 ± 6.86 LDH (U/L) C 122.00 ± 18.23 1040.17 ± 475.47** 2271.00 ± 658.04** 2412.50 ± 676.63** 2325.00 ± 1022.26** 877.50 ± 1017.30 266.33 ± 362.12 103.67 ± 47.72 B 93.33 ± 28.87 798.00 ± 469.14** 1701.17 ± 897.21** 1889.66 ± 1260.04** 1593.00 ± 1771.49** 577.83 ± 956.64 102.00 ± 19.98 81.67 ± 10.91 A 114.67 ± 30.63 125.50 ± 31.58 112.67 ± 23.07 121.67 ± 26.42 80.50 ± 26.75 78.50 ± 24.85 148.78 ± 215.19 79.25 ± 27.07 CK (U/L) C 1021.23 ± 743.63 2911.23 ± 1964.31* 3270.43 ± 1805.35*# 3518.48 ± 2036.64*# 3268.08 ± 2092.15**# 1297.10 ± 1188.05*# 473.22 ± 512.40 127.70 ± 52.17 B 975.37 ± 848.57 1334.60 ± 903.48 1545.82 ± 1094.05# 1549.25 ± 955.78# 1336.57 ± 951.31# 391.05 ± 235.24# 167.78 ± 120.44 97.63 ± 29.18 A 1051.68 ± 374.34 1261.10 ± 757.72 1375.90 ± 983.30 1361.80 ± 969.11 1684.22 ± 1745.32 143.43 ± 77.89 110.05 ± 61.35 123.35 ± 49.56 CK-MB (U/L) C 58.80 ± 8.14 426.80 ± 163.75**# 229.20 ± 78.78** 181.20 ± 51.50** 139.80 ± 51.72 71.40 ± 31.34 38.40 ± 7.89 41.20 ± 13.25 B 65.20 ± 44.71 208.00 ± 148.17# 147.00 ± 73.43 120.00 ± 67.02 97.60 ± 76.43 38.40 ± 11.61 50.60 ± 39.88 36.20 ± 12.46 A 78.50 ± 42.07 83.33 ± 59.90 90.17 ± 73.23 66.00 ± 26.69 74.67 ± 79.22 53.17 ± 56.44 42.12 ± 25.73 37.00 ± 11.73 Glucose (µmol/L） C 5.58 ± 2.79 4.32 ± 1.05* 4.86 ± 2.38 4.00 ± 1.74 4.28 ± 1.53 4.68 ± 1.29# 4.44 ± 0.80# 4.66 ± 1.02 B 5.18 ± 0.73 5.10 ± 0.33 5.36 ± 2.23 5.26 ± 1.30 5.72 ± 1.57 6.24 ± 0.79*# 5.78 ± 0.58# 4.78 ± 0.46 A 6.26 ± 1.86 5.37 ± 0.58 5.67 ± 1.38 5.56 ± 1.14 5.30 ± 1.37 4.90 ± 0.93 5.20 ± 1.04 5.20 ± 1.04 * P<0.05, ** P<0.01 (compared to the control group A). #P<0.05, ##P<0.01 (B compared with C ). CK, Creatine Kinase;TBIL, Total bilirubin; CREA,Creatinine. C=2.5g/kg; B=1.5g/kg; A= 0g/kg

Table 1: Study findings *