All reported cyclosporine concentrations (n=522)
Groups Range Mean ± SD
Ke (hr-1) 0.03-0.9 (hr-1) 0.159 ± 0.061 (hr-1)
t1/2 (hr) 0.77- 83.8 (hr) 5.1 ± 3.87 (hr)
V/F (L) 22.23-1819.7 (L) 129.79 ± 96.67 (L)
CL/F (L/hr) 5.15-48.93 (L/hr) 17.85 ± 5.9 (L/hr)
AUC (ng/ml/hr) 2348.5-14915.9 (ng/ml/hr) 9907.2 ± 818.23 (ng/ml/hr)
c0: (ng/mL) 16-959.1 (ng/ml) 180.7 ± 112.6 (ng/ml)
c2: (ng/mL) 110-1887.7 (ng/ml) 789.2 ± 355.6 (ng/ml)
Toxic cyclosporine concentrations (Trough level >300 ng/dl /Peak level>1000 ng/dl) (n=57)
Groups Range Mean ± SD
Ke (hr-1) 0.06-0.17 (hr-1) 0.08 ± 0.035 (hr-1)*
t1/2 (hr) 12.8- 83.8 (hr) 10.6 ± 7.34 (hr)**
V/F (L) 72.6-1819.7 (L) 260.29 ± 243.4 (L)*
CL/F (L/hr) 7.59-35.41 (L/hr) 18.66 ± 5.7 (L/hr)
AUC (ng/ml/hr) 5429.27-13575.6 (ng/ml/hr) 9836.1 ± 1010.61 (ng/ml/hr)
c0: (ng/mL) 301.1-959.1 (ng/ml) 439.9 ± 232.7 (ng/ml)
c2: (ng/mL) 725.2-1887.7 (ng/ml) 1007.6 ± 288.4 (ng/ml)
High normal cyclosporine concentration (Trough level 200-300ng/dl/Peak level 900-1000ng/dl) (n=125)
Groups Range Mean ± SD
Ke (hr-1) 0.03-0.8 (hr-1) 0.18 ± 0.19 (hr-1)
t1/2 (hr) 3.05-24.46(hr) 5.7 ± 1.9 (hr-1)
V/F (L) 44.39-441.22 (L/hr) 146.1 ± 62.5(L/hr)
CL/F (L/hr) 7.37-35.91 (L/hr) 17.96 ± 5.6 (L/hr)
AUC (ng/ml/hr) 8133.33-12192.9 (ng/ml/hr) 9933.42 ± 411.23 (ng/ml/hr)
c0: (ng/mL) 200.5-298.2 (ng/ml) 243.13 ± 28.8 (ng/ml)
c2: (ng/mL) 783.69-1767.6 (ng/ml) 912.1 ± 263.3 (ng/ml)
Normal cyclosporine concentration (Trough level 150-200/dl/Peak level 800-900 ng/dl) (n=151)
Groups Range Mean ± SD
Ke (hr-1) 0.03 -1.3 (hr-1) 0.21 ± 0.2 (hr-1)
t1/2 (hr) 3.31-21.65(hr) 4.9 ± 1.93 (hr-1)
V/F (L) 45.23-309.32 (L/hr) 125.27 ± 51.27(L/hr)
CL/F (L/hr) 7.17-34.46 (L/hr) 18.02 ± 6.1(L/hr)
AUC (ng/ml/hr) 5437.4-1083902 (ng/ml/hr) 9932.42 ± 448.94 (ng/ml/hr)
c0:(ng/mL) 150.0-199.7.2 (ng/ml) 174.77 ± 15.38 (ng/ml)
c2: (ng/mL) 411.1-1328.2(ng/ml) 783.8 ± 183.5 (ng/ml)
Ke: Elimination constant V: Volume of distribution F: Bioavailability CL: Clearance AUC: Area Under the Curve C0:Cyclosporine trough level C2:Cyclosporine peak level *P<0.05% **P ≤ 0.01%
Table 3: Pharmacokinetic or toxicokinetic sort of parameters under patients with renal transplanted for the diversified concentration of cyclosporine.