Parameter Group I Group II Group III Group IV Group V Group VI Group VII
after 1 month 2-4 months 4-6 months 6-8 months 8-10 months 10-12 months >12 moths
Cylosporine dosage (mg/kg) Mean ± SD 2.2 ± 0.8 2.4 ± 1.6 2.5 ± 1.6 2.6 ± 0.7 2.5 ± 0.7 2.5 ± 0.9 2.2 ± 0.9
Cylosporine trough level (ng/ml) Mean ± SD 188.9 ± 112.9 180.3 ±120.9 180.9 ± 97.7 166.6 ± 82.4 187.7 ± 75.6 176.5 ± 79.1 170.3 ± 91.3
Cylosporine peak level (ng/ml) Mean ± SD 841.1 ± 492.8 819.6 ± 339.8 756.3 ± 367.9 809.4 ± 317.7 867.6 ± 331.8 697.1 ± 290.9 762.4 ± 492.7
Serum creatinine (mg/dl) Mean ± SD 1.3 ± 0.3 1.2 ± 0.8 1.1 ± 0.8 1.5 ± 0.9 1.5 ± 0.8 1.4 ± 1.2 1.4 ± 0.9
Glomerular filtration rate (mL/min) Mean ± SD 94.5 ± 38.9 80.8 ± 37.3 81.1 ± 41.2 87.4 ± 66.9 95.4 ± 88.1 96.8 ± 47.5 96.9 ± 44.8
Blood urea-nitrogen level Mean ± SD 35.26 ± 22.9 48.17 ± 35.7 50.4 ± 35.3 47.5 ± 37.8 52.1 ± 31.9 46.1 ± 34.7 38.6 ± 32.1
Blood urea level Mean ± SD 32.6 ± 27.4 35.1 ± 39.5 46.5 ± 47.6 29.4 ± 35.3 26.6 ± 36.6 22.5 ± 11.2 33.4 ± 4
Serum Glutamic Pyruvic Transaminase (IU/L) Mean ± SD 32.9 ± 15.1 34.7 ± 17.7 35.3 ± 17.5 39.1 ± 20.4 33.1 ± 14.1 33.7 ± 14.6 29.9 ± 13.9
Serum Glutamic Oxaloacetic Transaminase (IU/L) Mean ± SD 20.2 ± 9.1 20.9 ± 15.2 21.1 ± 12.8 24.7 ± 18.7 25.1 ± 17.3 21.9 ± 13.1 21.7 ± 16.8
Serum Albumin Level (mg/dl) Mean ± SD 6.8 ± 3.4 4.4 ± 2.3 3.4 ± 0.6 3.4 ± 0.8 3.3 ± 0.5 3.8 ± 3.2 3.6 ± 0.6
Table 5: Dosage of cyclosporine, levels of trough-peak, hepatic as well as profiles of renal functions in renal transplantation under diversified post-transplant intervals (n=522).