Cause-of-Death Substances Involved
# Title ICD-10 Codes Poisoning Substance Use Disorders Pharmaceutical Adverse Event Prescription Opioids Heroin Cocaine and Other Drugs Unspecified Narcotics
1 National Center for Health Statistics drug poisoning Any underlying COD: X40-X44, X60-X64, X85, and Y10-Y14  
2 Acute or chronic poisonings due to the effects of drugs from ISW [9] Deaths with underlying COD: D52.1, D59 (.0, .2), D61.1, D64.2, E06.4, E16.0, E23.1, E24.2, E27.3, E66.1, F11-F16, F19, G21.1, G24.0, G25 (.1, .4, 6), G44.4, G62.0, G72.0, I95.2, J70 (.2-.4), K85.3, L10.5, L27 (.0, .1), M10.2, M32.0, M80.4, M81.4, M83.5, M87.1, R50.2, X40-X44, X60-X64, X85, Y10-Y14, or Y40-Y59
3 Acute poisonings due to the effects of drugs from ISW [9] Deaths with underlying COD: [F11 - F16] (.0), F19.0, X40-X44, X60-X64, X85, or Y10-Y14  
4 Acute or chronic drug poisonings associated with the effects of opium, heroin and/or opioid analgesics from ISW [9] Deaths with an underlying COD code: F11 or Y45.0 ----- or ----- Underlying cause-of-death: D52.1, D59 (.0, .2), D61.1, D64.2, E06.4, E16.0, E23.1, E24.2, E27.3, E66.1, F12-F16, F19, G21.1, G24.0, G25 (.1, .4, 6), G44.4, G62.0, G72.0, I95.2, J70 (.2-.4), K85.3, L10.5, L27 (.0, .1), M10.2, M32.0, M80.4, M81.4, M83.5, M87.1, R50.2, X40-X44, X60-X64, X85, Y10-Y14, Y40-Y44, or Y46-Y59 and Any contributing COD: F11, T40.0, T40.1, T40.2, T40.3, T40.4, T40.6  
5 Acute drug poisonings associated with the effects of opium, heroin and/or opioid analgesics from ISW [9] Deaths with underlying COD: [F11 - F16] (.0), F19.0, X40-X44, X60-X64, X85, or Y10-Y14 and Any contributing COD: F11.0, T40.0, T40.1, T40.2, T40.3, T40.4, T40.6      
6 Acute drug poisonings associated with the effects of opioid analgesics from ISW [9] Deaths with an underlying COD: [F11 - F16] (.0), F19.0, X40-X44, X60-X64, X85, or Y10-Y14 and Any contributing COD: T40.2, T40.3, T40.4          
7 All possible opioid-related deaths Australian surveillance definition [8] "Opioid toxicity” means T40.0 to T40.4 and T40.6 are present in any contributing COD field. Any death that has: (1) underlying COD F11.0-F11.9; (2) underlying COD X42, with contributing COD opioid toxicity; (3) underlying COD X44, with contributing COD opioid toxicity; (4) underlying COD F19.0-F19.9, with either contributing COD opioid toxicity, or F11.0-F11.9; (5) underlying COD X60-X69 with opioid toxicity; (6) underlying COD Y10- Y19 with opioid toxicity; (7) underlying COD F10, F12-F18 with opioid toxicity; (8) underlying COD X85 with opioid toxicity; (9) underlying COD X40-X41 or X43-X49 with opioid toxicity; (10) any underlying COD with opioid toxicity not otherwise specified; (11) any underlying COD with F11.0 through F11.9 as a contributing COD  
8 Proposed definition of overdoses involving controlled substances See Table 5    
Table 1: ICD-10-based definitions for identifying drug overdose deaths.