Figure 2: ABR threshold shifts. (a) Shift of the frequency average after a single furosemide injection. The shift was largest (approximately 53 dB) 30 min after furosemide application (the earliest time tested) and recovered at 12 h. (b) Threshold shift audiogram 7 days after consecutive cisplatin injections (3 mg/kg × 5d). The shift was biased to high frequencies (up to 50 dB) and was lower at lower frequencies (around 30 dB). (c) Threshold shift audiogram 7 days after co-administration of 200 mg/kg furosemide and various Cis doses. Cis was administered 30 min after furosemide. (d) Threshold shift audiogram 7 days after co-administration of 0.2 mg/kg Cis and 200 mg/kg furosemide at various intervals. The threshold shift was nearly zero at a zero interval and higher at longer intervals.