Figure 2: A schematic diagram of a model by which cardiotoxin Vc5 enables the fusion of liposomes. Vc5 can simultaneously interact with two liposomes containing a mixture of phosphatidylcholine and cardiolipin by interacting with the outer leaflet of each liposome. Phospholipids shown in yellow are anionic phospholipids (PS and CL). Please note that the hydrophilic region of cardiotoxin (basic N-terminal region; shaded region of cardiotoxin) can sequester either PS or CL molecules away (yellow phospholipid heads) from one of the leaflets of the lipid bilayer while the hydrophobic region of cytotoxin interacts with the alkyl tails of the phospholipids.