Patient characteristics n (%)
Demographic data Patients included (hereof male) 259 (190 or 73%)
Age ± SD [male/female], years 68 ± 11[68 ± 11/68 ± 12]
BMI ± SD [male/female], kg/m2 27 ± 4 [27 ± 4/26 ± 6]
Risk factors for cardiovascular disease Hypertension 170 (66)
Hypercholesterolemia 170 (66)
Diabetes mellitus, on insulin 35 (14)
Smoker/ex-smoker 122 (47)/21 (8)
Extracardiacarteriopathy 18 (7)
Previous stroke 26 (10)
Alcohol overuse 48 (19)
Clinical features Left ventricular ejection fraction >50 152 (59)
31-50 62 (24)
21-30 18 (7)
<21 10 (4)
Not reported 17 (7)
Glomerular filtration rate ml/min/1.73 m2 >85 72 (28)
50-85 132 (51)
<50 52 (20)
Not reported 3 (1)
New York Heart Association class 1 81 (31)
2 86 (33)
3 74 (29)
4 8 (3)
Not reported 10 (4)
CCS class 4* 13 (5)
Recent myocardial infarction 65 (25)
Chronic obstructive pulmonary disease 40 (15)
Poor mobility 16 (6)
Surgical conditions Critical preoperative state 9 (3)
Elective/urgent/emergency 207/43/9
Number of procedures 1/2/3 190/73/6
Active endocarditis 4 (2)
Postoperative findings O2 saturation ± SD 97± 7
Potassium ± SD 4.2± 0.5
Number of QT prolonging drugs administered Average 1.37
1 117 (45)
2 30 (12)
3 12 (5)
4 3 (1)
QTc duration ± SD, ms All [male/female] 462 ± 43 [458 ± 43/472 ± 41]
QTc 481-500 ms (%) All [male/female] 22 (9) [15(8)/7(10)]
QTc>500 ms (%) All [male/female] 47(18) [30(16)/17(25)]
*CCS class = Canadian cardiovascular society angina classification. Class 4 is angina at any level of exertion including rest.
Table 1: Clinical characteristics of patients included in the Prolonqit study.