Figure 4: (A and B) Low- and high-magnification images (hematoxylin and eosin stain) of the ascending aorta including the origin of the coronary artery from a rat dosed for 14 weeks with LY2157299. The origin of the coronary artery has disruption of the tunica media with transmural infiltration by mixed inflammatory cells. (C and D) Low- and high-magnification images from a rat dosed for 6 months with LY2157299. The coronary artery has a pronounced perivascular infiltration of mixed inflammatory cells with only limited involvement of the tunica media.