Species Duration (weeks) Recovery (Weeks) Dosing Regimen N (sex/group) Doses (mg/kg)
Rat 2 None Daily 5 0, 50, 300, 1200
  4 4 Daily 10 0, 15, 50, 150
  12 None Daily 10 0, 50, 150, 250
  12 None 2 weeks on 2 weeks off 10 0, 50, 150, 250
  8 6 Daily 10 (control) 35 (treated) 0, 250
  26 None Daily 15 0, 50, 150, 250
Dog 4 4 Daily 3 0, 50, 250, 500
  4 None Daily 3 0, 2, 8, 20
  26 None Daily 4 0, 8, 20, 60
Table 1: Nonclinical Studies Conducted with LY2157299.